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α orc1  (Cell Signaling Technology Inc)


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    Structured Review

    Cell Signaling Technology Inc α orc1
    (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the <t>ORC1</t> KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.
    α Orc1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α orc1/product/Cell Signaling Technology Inc
    Average 93 stars, based on 39 article reviews
    α orc1 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Regulation of epigenetics and chromosome structure by human ORC2"

    Article Title: Regulation of epigenetics and chromosome structure by human ORC2

    Journal: bioRxiv

    doi: 10.1101/2024.12.18.629220

    (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the ORC1 KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.
    Figure Legend Snippet: (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the ORC1 KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.

    Techniques Used: Gene Expression, RNA Sequencing



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    α orc1  (Cell Signaling Technology Inc)
    93
    Cell Signaling Technology Inc α orc1
    (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the <t>ORC1</t> KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.
    α Orc1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α orc1/product/Cell Signaling Technology Inc
    Average 93 stars, based on 1 article reviews
    α orc1 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the ORC1 KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.

    Journal: bioRxiv

    Article Title: Regulation of epigenetics and chromosome structure by human ORC2

    doi: 10.1101/2024.12.18.629220

    Figure Lengend Snippet: (A) Schematic of experiment. (B-C) Chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) changes in ORC1KO. Signals significantly up-regulated (red) or down-regulated (blue) in the ORC1 KO cells. (D-E) Same as (B-C) except for ORC5KO cells relative to WT. (F-G) Venn diagram showing overlap of ATAC changes in the three KO cells. (H) Example ORC2-dependent ATAC changes. (I-J) Venn diagram showing overlap of gene expression changes in the three KO cells.

    Article Snippet: Antibodies used include α-ORC1 (cell signaling technology, no. 4731), α-ORC2 (Santa Cruz Biotechnology, no. sc-32734), α-ORC3 (Santa Cruz Biotechnology, no. sc-23888), α-ORC4, α-ORC5, α-ORC6 (PMID15944161), α-HSP90 (Santa Cruz Biotechnology, no. sc-13119), α-MCM7 (Santa Cruz Biotechnology, no. sc-9966), α-ORCA (PMID 20932478, generous gift from Supriya G. Prasanth, University of Illinois), α-HP1α (cell signaling technology, no. 2616), α-H3K9ME1 (cell signaling technology, no. 14186), α-H3K9ME2 (cell signaling technology, no. 4658), α-H3K9ME3 (cell signaling technology, no. 13969), α-HBO1 (cell signaling technology, no. 58418), α-H3K27ME3 (cell signaling technology, no. 9733), α-Histone H3 (cell signaling technology, no. 4499), α-NFIA (Apcepta, no. AP20998c), α-CHD7 (cell signaling technology, no. 6505).

    Techniques: Gene Expression, RNA Sequencing